Dr Greenfield


Polypharmacy, Monotherapy, Deprescribing, and Vindication

Who doesn’t enjoy the opportunity to say “I told you so?”

Perhaps only the most self-critical and masochistic individual doesn’t like to be vindicated. What follows in this piece is the story of vindication for the way we do certain things — and always have done certain things — at the Little Hill Foundation.

In psychiatric practice, as in so many areas of human activity, the pendulum of trends in prescribing psychotropic (“acting on the mind,” or “psyche”) medications has swung widely over the years: From disinterest and avoidance of these medications (during the psychanalytic era in the first half of the twentieth century); to the guarded but hopeful use of limited psychotropic agents (in the 1960’s and 1970’s); to the acceptance of tailored and specific “monotherapy,” or use of single agents for patients (in the 1980’s and 1990’s”);* to “polypharmacy,” the enthusiastic and wholesale prescribing of multiple psychotropic medication for multiple presumed clinical diagnoses in the same individual (in the 1990’s and 2000’s); to a recent backlash movement against polypharmacy called “deprescribing” (over the past several years).

“It is an art of no little importance to administer medicines properly;
But it is an art of much greater and more different acquisition to Know when to suspend or quit them altogether.”
Philippe Pinel (1745-1826)

At Alina Lodge and Haley House from the beginning (1957 & 2007), the conservative and minimalist approach to pharmacotherapy has recognized on the one hand that pharmacologic solutions to the problems of chemical and behavioral addictions run counter to the core abstinence and 12-step recovery treatment philosophy of the Little Hill Foundation treatment programs, and on the other, that virtually all the of the students and residents at Alina Lodge and Haley House are in treatment” to Little Hill’s way of doing things, but through what has been termed “deprescribing,” mainstream psychiatry has begun to do just that.

*In the often-quoted, somewhat paraphrased, words of Harvard Medical School/Massachusetts General Hospital child psychiatrist, Leon Eisenberg, MD, in about 1995, “Let’s not allow the brainlessness of psychiatry in the 1930’s through 1950’s be replaced with the mindlessness of psychiatry in the 1980’s and 1990’s…”

As recently defined, “deprescribing” is “…the planned and supervised process of dose reduction or stopping of medication that might be causing harm, or no longer be of benefit… backing off when doses are too high, or stopping medications that are no longer needed…”2

The process of “deprescribing” has been applied predominantly to geriatric medicine,3 in which multiple prescribing (“polypharmacy”) characteristically occurs for multiple organ systems and includes proton pump inhibitors (“PPI’s”; for acid reflux disease), diabetic medications, cardiac medications and hypertensive agents, cholesterol-lowering medications, psychotropic agents, and a variety of others. The following Figure, adapted from Moriarty and Farrell and the WHO4, illustrates general principles for prescribing those medications and strategies for tapering, and where indicated, discontinuing, such medications.

Coming full circle, the closing words from the instruction sheet on “The Role of Psychiatry at Alina Lodge”5 — given to new students on their admission to Alina Lodge — ring true under the concept of “deprescribing”:

…Finally, for those students whose symptomatology is due to a bonafide underlying disorder, Psychiatry at Alina Lodge will maintain them on appropriate psychotropic medications, monitor and supervise necessary changes, and provide necessary pharmacotherapy for them…”



  • Greenfield, D.P., “The Role of Psychiatry in Addiction Treatment” Little Hill Foundation Newsletter, ____:1, 3, Fall 2017
  • Position statement of the Bruyére Research Institute (Ottawa, Canada/Centre de recherche, Institut universitaire de gériatrie de Montréal)
  • Hardy, JE and SN Hilmer, “Deprescribing in the Last Year of Life,” Geriatric Therapeutics, 42(2): 1, April 13, 2015
  • Moriarty, F. and B. Farrell, “Deprescribing recommendations: An essential consideration for clinical guideline developers, ” Research in Social and Administrative Pharmacy, September 18, 2018
  • Greenfield, D.P. “The Role of Psychiatry at Alina Lodge,” student information sheet, 2016



Daniel P. Greenfield, MD, MPH, MS

Psychiatric Consultant, Little Hill Foundation
Clinical Professor of Neuroscience (Psychiatry), Seton Hall University

Alina Lodge

Little Hill Foundation is a 501(c)(3) not-for-profit that operates Alina Lodge, Haley House and North Warren Counseling Center (NWCC):

Alina Lodge treats all types of chemical dependency such as alcoholism and drug addictions including cocaine, heroin, marijuana, methamphetamine, as well as prescription drug addiction. If you or a loved one struggles to stay sober, contact us today.

Haley House is a leading halfway house for women seeking transitional living environment leveraging the 12 step program after completing primary treatment for addiction. Contact us today.

NWCC offers comprehensive outpatient mental health and substance abuse treatment for local, communities surrounding Blairstown, New Jersey. Contact us today.

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